Robert Langreth. A New Look At Alzheimer's (09.16.09, 06:00 PM EDT) Forbes Magazine Dated October 05, 2009
Have researchers been barking up the wrong tree?
Excerpt: "...Alzheimer's disease is a bit like a murder mystery with numerous possible culprits and only a few vague clues. For years the prime suspect has been a protein fragment called beta-amyloid, which forms clumps inside the brains of dementia patients. Big drug companies since the 1990s have bet heavily on the concept that amyloid poisons brain cells and that blocking it will halt a patient's devastating decline.
But even as their drugs move into final human trials, the evidence implicating amyloid is starting to look a little shaky. An amyloid-lowering drug from Myriad Genetics ( MYGN - news - people ) did nothing in a giant trial. Wyeth ( WYE - news - people ) and Elan ( ELN - news - people )'s amyloid-clearing antibody, called bapineuzumab, showed mixed results in a midstage human trial last year. It clearly helped only a subset of patients who lacked a certain gene mutation, and it had side effects such as fluid leakage in the brain.
Stranger yet, this summer researchers from the Mount Sinai School of Medicine in New York City examined an old allergy drug from Russia that recently showed promising results in Alzheimer's victims. They wanted to know whether it lowered amyloid. To their surprise, it boosted short-term amyloid levels in animal and lab experiments, according to results reported at a big Alzheimer's conference. Pfizer ( PFE - news - people ) licensed comarketing rights for the Russian antihistamine from the biotech company Medivation ( MDVN - news - people ) in 2008 for $225 million plus milestone payments, and the companies are conducting large trials. Results are due next year.
All of this has some scientists wondering if they are targeting the wrong chemical. "People inside and outside the amyloid field are trying to think what are we doing wrong. Either we are treating the wrong thing or using the wrong drug or treating it in the wrong way," says Mount Sinai's Samuel Gandy, who led the research into the Russian drug and still thinks amyloid is involved. Adds Merck ( MRK - news - people ) Vice President Richard Hargreaves: "There has been a sort of a narrow-minded approach to Alzheimer's disease. Amyloid deposition is only one of the features."
Some go much further. "I think amyloid is a complete nothing," says University of Aberdeen (Scotland) researcher Claude Wischik. "One day someone has to write a book about how a whole field can get suckered into this for so long." ...read on full article at forbes.com
Alex Koudinov-Sheffer note: Well... www.alclub.org is all about shoing the public, not just field insiders, ethically corrupted for one reason (stock shares) or another (grant support for amyloid theory or a need to support amyloid because of tenure promotion)))
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